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Extracutaneous Merkel cell carcinoma or metastatic Merkel cell carcinoma with an occult primary?

Merkel cell carcinoma (MCC) is a rare and aggressive malignancy arising from dermal neuroendocrine cells, first described by Toker in 1972 [1]. It is predominately seen in the head and neck region of older, white males and risk factors include...

Chronic telogen effluvium reversal using E. coli-derived cytokines and growth factors: a case report

Chronic telogen effluvium (CTE) is a condition where there is prolonged increased hair shedding, primarily affecting middle-aged women. Its exact cause is often unknown. In CTE, many hair follicles enter the resting phase prematurely due to various reasons, leading to...

Part four: Aye, Aye. AI?

“Formal clinical guidelines would provide a structured, evidence-based approach to managing patients who have undergone melanoma treatment and are considering elective surgery. This would enhance patient safety, standardise care, and support informed decision-making. Given the increasing prevalence of melanoma and...

Exosomes: everything you always wanted to know and questions to ask your exosome provider

This article has been verified for CPD. Click the button below to answer a few short questions and download a form to be included in your CPD folder. What are exosomes? Exosomes are just one subset of extracellular vesicles (EVs),...

Laser and light-based treatments for pigmented lesions

The authors detail the types of lasers and light-based devices that can be used in the treatment of epidermal and dermal pigmentations. Skin colour differences have, for centuries, been associated with the economic, political and social status of a person;...

Laser and light based hair removal

Laser hair removal is a popular, and constantly evolving, treatment. Professor Paolo Bonan and colleagues provide us with a comprehensive overview and some ‘top tips’ for how to make the procedure as safe and effective as possible. Hair removal, also...

An overview of chemical peels

Chemical peels form an important part of most aesthetic and cosmetic practices. They are an affordable procedure for patients and significant results can be achieved. Generally chemical peels are a safe procedure, but only if used correctly and with caution....

Non-surgical management of actinic keratosis, Bowen’s disease and non-melanoma skin cancer

Non-melanoma skin cancers (NMSCs) are primary cutaneous neoplasms comprising mainly of basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs). In 2011, 102,628 cases of NMSCs (74% BCC and 23% SCC) were recorded in England, making NMSC the most common...

The future and a summary of the past

From liposuction to adipose stem cells; from regenerative medicine to tissue engineering; and a vision of the future. Part 3 Adipose stem cells There is a major clinical need for strategies that adequately reconstruct the soft tissue defects after deep...

The importance of skin preparation

With both aesthetic procedures and antibiotic resistance on the rise, good skin disinfection to reduce the risk of infection is more vital than ever. Anna Baker takes us through the evidence behind commonly used skin preparation formulations for aesthetic injectable...

The gender affirmation surgery MDT

The authors provide a comprehensive and thought-provoking discussion of the multidisciplinary nature of caring for someone undergoing gender reassignment surgery. In the last 50 years in the UK an estimated 130,000 people have changed their gender assigned at birth (assigned...

Soft tissue augmentation – a review

The author explains how treating the face as a 3D structure is key to a good result with invasive or non-invasive procedures. History Rejuvenation of the face and trying to reverse the effects of ageing dates back centuries. Facial volume...